The Yellow Fever Commission, founded as a consequence of excessive disease mortality during the Spanish–American War (1898), concluded that the best way to control the disease was to control the mosquito. William Gorgas successfully eradicated yellow fever from Havana by destroying larval breeding sites and this strategy of source reduction was then successfully used to reduce disease problems and thus finally permit the construction of the Panama Canal in 1904. Success was due largely to a top-down, military approach involving strict supervision and discipline.
- Gorgas WC. Sanitation in Panama. Appleton & Co.; New York: 1915.